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BA., Willamette University; Ph.D., University of California, Santa
Barbara.
Hired: 2001; Rank: Associate Professor of Chemistry, 2005
Office: Olin Science Center 316
Phone: 503-370-6417
email: kholman@willamette.edu
Courses Taught:
Chem 115 Introductory Chemistry I
Chem 116 Introductory Chemistry II
Chem 342Y/343Y Instrumental and Experimental
Chemistry Laboratory
Chem 362 Inorganic Chemistry
Chem 430 Advanced Topics: Spectroscopic Methods in Inorganic Chemistry
Chem 430 Advanced Topics: Bioinorganic Chemistry
IDS 101 College Colloquium: Blues Music and Culture of the Mississippi Delta
Professional Interests: Dr. Holman and her student collaborators are investigating fundamental chemistry related to the mechanisms of action of ruthenium anti-cancer drugs. The primary techniques employed are infrared spectroelectochemistry and X-ray absorption spectroscopy (XAS). The XAS studies are carried out on beamline 9.3.1 at the Advanced Light Source, Lawrence Berkeley National Laboratory. Dr. Holman currently serves on the Executive Committee of the Stanford Synchrotron Radiation Laboratory (SSRL) Users’ Organization, and she is planning to expand her experiments onto beamlines 6-2 and 9-3 at SSRL in 2007-08.
Other research projects carried out by students in Dr. Holman’s laboratory relate to bonding and ligand exchange mechanisms in bioinorganic systems (in collaboration with Dr. Kirk), photochemistry of inorganic complexes (in collaboration with Dr. Williamson), and phytoremediation of metals (in collaboration with Dr. Goodney).
Personal Interests: Playing guitar (punk/rock & roll), community radio, hiking, yoga, travel,
and family.
[Faculty Profiles] [Department
Overview]
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Publications :
S. R. Kirk, T. P. Silverstein, K. L. McFarlane Holman and B. H. Taylor. “Probing Changes in the Conformation of tRNA( Phe) : An Integrated Biochemistry Laboratory Course”, J. Chem. Ed. Submitted, manuscript 0474 (2006).
R. M. Cinco, J. H. Robblee, J. Messinger, C. Fernandez, K. L. M. Holman, K. Sauer and V. K. Yachandra. “Polarized Strontium EXAFS of Photosystem II Membranes Reveals the Orientation of the Calcium Cofactor in the Oxygen-Evolving Complex”, Biochemistry, 43(42), 13271-13282 (2004).
K. L. McFarlane Holman, M. J. Latimer and V. K. Yachandra. “A Liquid Helium Cryostat with Internal Fluorescence Detection for X-ray Absorption Studies in the 2-6 keV Energy Region”, Review of Scientific Instruments, 75, 2056-2060 (2004). (This publication was also selected to appear in the June 2004 issue of Virtual Journal of Biological Physics Research.)
R.M. Cinco, K.L. McFarlane Holman, J.H. Robblee, J.Yano, S.A. Pizarro, E. Bellacchio,
K. Sauer and V.K. Yachandra. "Calcium EXAFS Establishes the Mn-Ca Cluster
in the Oxygen-Evolving Complex of Photosystem II", Biochemistry, 41(43),
12928-12933 (2002).
J.H. Robblee, J. Messinger, R.M. Cinco, K.L. McFarlane, C. Fernandez, S.A.
Pizarro, K. Sauer, V.K. Yachandra. "The Mn Cluster in the S-O State of
the Oxygen-Evolving Complex of Photosystem II Studied by EXAFS Spectroscopy:
Are There Three di-mu-oxo-bridged Mn-2 Moieties in the Tetranuclear Mn Complex?"
J. Am. Chem. Soc., 124(25), 7459-7471 (2002).
J. Messinger, J.H. Robblee, U. Bergmann, C. Fernandez, P. Glatel, H. Visser,
R.M. Cinco, K.L. McFarlane, E. Bellacchio, S.A. Pizarro, S.P. Cramer, K. Sauer,
M.P. Klein, and V.K. Yachandra. "Absence of Mn-Centered Oxidation in the
S2 to S3 Transition: Implications for the Mechanism of Photosynthetic Water
Oxidation" J. Am. Chem. Soc., 123(32), 7804-7820 (2001).
E. Bellacchio, K.L. McFarlane, A. Rompel, J.H. Robblee, R.M. Cinco, K. Sauer,
M.P. Klein, and V.K. Yachandra. "Counting the Number of Disulfides and
Thiol Groups in Proteins and a Novel Approach for Determining the Local pKa
for Cysteine Groups in Proteins in vivo" , J. Synchrotron Rad., 8(3), 1056-1058
(2001).
A. Rompel, R.M. Cinco, J.H. Robblee, M.J. Latimer, K.L. McFarlane, J. Huang,
M.A. Walters, and V.K. Yachandra. "S K- and Mo L-Edge X-Ray Absorption
Spectroscopy to Determine Metal-Ligand Charge Distribution in Molybdenum-Sulfur
Compounds" , J. Synchrotoron Rad., 8(2), 1006-1008 (2001).
U. Bergmann, P. Glatzel, J.H. Robblee, J. Messinger, C. Fernandez, R. Cinco,
H.Visser, K. McFarlane, E. Bellacchio, S. Pizarro, K. Sauer, V.K. Yachandra,
M.P. Klein, B.L. Cox, K.H. Nealson, and S.P. Cramer. "High-resolution X-ray
Spectroscopy of Rare Events: a Different Look at Local Structure and Chemistry"
, J. Synchrotron Rad., 8(2), 199-203 (2001).
J.H. Robblee, J. Messinger, C. Fernandez, R.M. Cinco, H. Visser, K.L. McFarlane,
U. Bergmann, P. Glatzel, S.P. Cramer, K. Sauer, V.K. Yachandra, M.P. Klein "Oxidation
states of the Mn cluster in the S-states of the oxygen-evolving complex of PSII",
J. Inorg. Biochem., 74, 278 (1999).
R.M. Cinco, C. Fernandez, J. Messinger, J.H. Robblee, H. Visser, K.L. McFarlane,
U. Bergmann, P. Glatzel, S.P. Cramer, K. Sauer, V.K. Yachandra and M.P. Klein.
"Refined Model of the Oxidation States and Structures of the Mn/Ca/Cl Cluster
of the Oxygen Evolving Complex of Photosystem II", Photosynthesis: Mechanisms
and Effects, Vol. II, G. Garab, Ed.; Kluwer Acad. Publishers, The Netherlands,
1998; pp. 1273-1278.
K.L. McFarlane, B. Lee, W. Fu, R. van Eldik, and P.C. Ford. "Reactive
Intermediates in the Photodecarbonylation of the Cyclopentadienyl and Indenyl
Complexes CpFe(CO)2(C(O)CH3) and IndFe(CO)2(C(O)CH3) (Cp = h5-C5H5; Ind =
h5-C9H7)", Organometallics, 17, 1826-1834 (1998).
K.L. McFarlane and P.C. Ford. "Room Temperature Reactions of the Intermediate(s)
Generated by Flash Photolysis of (h5-C5H5)Fe(CO)CH3", Organometallics,
17, 1166-1168 (1998).
K.L. McFarlane, B. Lee, J. S. Bridgewater and P.C. Ford. "Time Resolved
Infrared Spectroscopy as a Technique to Study Reactive Organometallic Intermediates",
J. Organoment. Chem., 554, 49-61 (1998).
W.T. Boese, K.L. McFarlane, B. Lee, J. Rabor and P.C. Ford. "Photochemistry
as a Tool for Elucidating Organometallic Reaction Mechanisms", Coord. Chem.
Rev., 159, 135-151 (1997).
P.C. Ford, W.T. Boese, B. Lee and K.L. McFarlane. "Photocatalysis Involving
Metal Carbonyls", Chapter 12 in Photosensitization and Photocatalysis by
Inorganic and Organometallic Compounds, M. Graetzel and K. Kalyanasundaram,
Eds.; Kluwer Acad. Publishers, The Netherlands, 1993.