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BA., Brandeis University; M.S., Ph.D., University of California, Berkeley.
Hired: 1989; Rank: Professor of Chemistry, 1999
Office: Olin 317
Phone: 503-375-5359
email: tsilvers@willamette.edu
Courses Taught:
Chem 110 Chemical Concepts and Applications
Chem 115 Introductory Chemistry I
Chem 116 Introductory Chemistry II
Chem 351 Biochemistry
Chem 431 Advanced Topics in Biochemistry
Professional Interests: Biological membranes and bioenergetics; excitable
membranes and energy transduction; sensory signal transduction; enzyme
inhibition by toxic heavy metals.
Interests: I am a folk musician (tinwhistle, bouzouki, guitar,
mandolin, sax), dance caller (contras and squares), singer and dancer;
I bicycle as well.
[Faculty Profiles] [Department
Overview]
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PUBLICATIONS (REFEREED ARTICLES):
S.R. Kirk*, T.P. Silverstein, K.M. Holman, and B.L.H. Taylor (2007) “Probing Changes in the Conformation of tRNA Phe: An Integrated Biochemistry Laboratory Course” J. Chem. Educ. (submitted July 2006, ms # 2006-0474.)
S. Kirk, T.P. Silverstein, and J. Willemsen (2006) “Teaching Biologically Relevant Chemistry Throughout the Four-Year Chemistry Curriculum” J. Chem. Educ. 83(8), 1171-1175.
T.P. Silverstein (2005) “The Mitochondrial Phosphate-to-Oxygen Ratio is Not an Integer” Biochem. Mol. Biol. Educ. 33 (Nov.): 416 - 417.
T.P. Silverstein (2005) “The Reaction Quotient (Q) IS Useful After All” J. Chem. Educ. 82(8), 1149.
T.P. Silverstein (2005) “Redox Redux: A Response to Feinman’s “Oxidation-Reduction Calculations in the Biochemistry Course” Biochem. Mol. Biol. Educ. 32, 161–166.
S. Stavrianeas and T. Silverstein (2005) “Teaching Glycolysis Regulation to Undergraduates Using an Electrical Power Generation Analogy” Adv. Physiol. Educ. 29:128-130.
T.P. Silverstein (2004) “Proposed Improvements to the Lab ‘Equilibrium Binding of Phenol Red to Protein’ ” J. Chem. Educ. 81(5), 645.
T.P. Silversetin (2004) "Evaluating Weak vs. Tight Coomassie Blue-Protein
Binding" J. Chem. Educ. 81(3), 335.
T.P. Silverstein (2004) "Using a Graphing Calculator to Determine a First-Order
Rate Constant" J. Chem. Educ. 81(4), 485.
T.P. Silverstein (2004) "Suggestions to Expand the Lab Project 'The Sweetness
of Aspartame'" J. Chem. Educ. 81(2), 197.
T.P. Silverstein (2004) "Cohesive and Adhesive Forces vs. Surface Tension
Gradients-Revisited" J. Chem. Educ. 81(1), 35.
T.P. Silverstein (2003) "Ant Velocity: Temperature Dependence and Activation
Energy of a Complex Biological Process" J. Chem. Educ. 80(11), 1257.
T.P. Silverstein (2000) "Equilibrium: A Teaching/Learning Activity"
J. Chem. Educ. 77(11), 1410.
T.P. Silverstein (2000) "Graphing Calculator Strategies for Solving Chemical
Equilibrium Problems" J. Chem. Educ. 77(9), 1120.
T.P. Silverstein (2000) "Weak vs. Strong Acids and Bases: The Football
Analogy" J. Chem. Educ. 77(7), 849-50.
T.P. Silverstein (1999) "The Big Dog/Puppy Dog Analogy for Resonance"
J. Chem. Educ. 76(2), 206-7.
T.P. Silverstein (1998) "Why Do Alcoholic Beverages Have 'Legs'?"
J. Chem. Educ. 75(6), 723-724.
T.P. Silverstein and Yi Zhang (1998) "Sugar Dehydration Without
Sulfuric Acid: No More Choking Fumes in the Classroom!" J.
Chem. Educ. 75(6), 748-9.
T.P. Silverstein and E.R. Johnson (1998) "The Effect of Cooking on the
Vitamin C Content of Green Pepper"Chem. Educ. Resources (ANAL 501)
T.P. Silverstein (1998) "The Real Reason Why Oil and Water Don't Mix"
J. Chem. Educ. 75(1), 116-118.
Y. Zhang and T.P. Silverstein (1997) "The Use of Cyanide at Heap Leach
Gold Mines: Safe, Effective Mining Technique or Environmental Nightmare?"
Willamette Journal issue #11, pp. 1-23.
T.P. Silverstein, N.J. Hudak, F.H. Chapple, D.E. Goodney, C.P. Brink,
and J.P. Whitehead (1997) "Scientific Communication and the Unified Laboratory
Sequence" J. Chem. Educ. 74(2), 150-152.
H. Akers, T.P. Silverstein, J. Sipe (1995) Instructor's Manual for Zubay's
Biochemistry, 3rd edn., Wm. C. Brown, Dubuque, IA, ISBN 0-697-14268X
T.P. Silverstein (1995) "Breaking Bonds vs. Chopping Heads: The
Enzyme as Butcher" J. Chem. Educ. 72 (7), 645-646.
T.P. Silverstein (1995) "The Physical Reality of Molecules: They're
Dense and They Move Around!" J. Chem. Educ. 72(2), 177.
C.P. Brink, D.E. Goodney, N.J. Hudak, and T.P. Silverstein (1995) "A
Novel Spiral Approach to Introductory Chemistry Using Case Studies of Chemistry
in the Real World" J. Chem. Educ. 72(6), 530-532.
T.P. Silverstein and N.J. Hudak (1994) "Where Have all the Chem Majors
Gone?" CUR Quarterly 14(3), 127-130.
T.P. Silverstein, L. Cheng, and J.F. Allen (1993) "Chloroplast Thylakoid
Protein Phosphatase Reactions are Redox-Independent and Kinetically Heterogeneous"
FEBS Lett. 334(1), 101-105.
T.P. Silverstein, L.Cheng, and J.F. Allen (1993) "Redox Titration of
Multiple Protein Phosphorylations in Pea Chloroplast Thylakoids" Biochim.
Biophys.
Acta 1183, 215-220.
T.P. Silverstein et al (1993) : "Transmembrane Measurements Across
Bioenergetic Membranes" Biochim. Biophys. Acta 1183, 1-3.
T.P. Silverstein (1993) "Polarity, Miscibility, and Surface Tension
of
Liquids" J. Chem. Ed. 70(3), 253.
T.P. Silverstein and L.E. Blomberg (1992) "Probing Denaturation by Moni-
toring Residual Enzyme Activity and Intrinsic Fluorescence: An Under-
graduate Biochemistry Experiment." J. Chem. Ed. 69(10), 852-855.
H. Rottenberg, T. Silverstein, K. Hashimoto, S. Steiner-Mordoch (1990)
"ATP Synthesis Driven by Intramembranal Protons" in Molec. Struct.
,Func. ,& Assembly of
ATP Synthases, ed. S. Marzuki, Plenum, NY, pp. 195-203.
T.P. Silverstein (1989) "Evolution of ATP Synthases" Trends Bchem. Sci.14,
480.
INVITED TALKS AND CONFERENCE PRESENTATIONS:
S.R. Kirk, K.M. Holman, T.P. Silverstein (2005) “Integrated Advanced Biochemistry Laboratory: A Case Study Using tRNA(Phe)” CHED #262 at the 229th Amer. Chem. Soc. National Meeting, March 2005, San Diego, CA
D.E. Goodney, T.P. Silverstein, K.M. Holman, S.R. Kirk, J.J. Willemsen, and J.C. Williamson (2005) “Using Case Studies of Chemistry in the Real World to Teach Second Semester Introductory Chemistry” CHED #252 at the 229th Amer. Chem. Soc. National Meeting, March 2005, San Diego, CA
T.V. Harris, M. Ericksen and T.P. Silverstein (2004) “Further Confirmation of Mercury(II) Inhibition of Chymotrypsin via Binding to Histidine.” 13th Regional Conference on Undergraduate Research (Murdock College Science Research Program), Lewis and Clark College, Portland, OR; Nov. 2004.
M. Ericksen and T.P. Silverstein (2004) “Mercury(II) Inhibits Chymotrypsin by Binding to Histidine, Not Cysteine, Side Chains.” 227th Amer. Chem. Soc. National Meeting, Anaheim, CA, Mar. 2004, and IUBMB/ASBMB annual conference, Boston, MA; June 2004; FASEB J. 18(8), page C139, #65.12.
M. Ericksen and T.P. Silverstein (2003) "Inhibition of Chymotrypsin by
mercuric chloride: Surprisingly, the effect is not cysteine-related." 12th Regional
Conference
on Undergraduate Research/Murdock College Science Research Program,
Pacific Lutheran Univ., Tacoma, WA; 7-8 Nov. 2003.
E. Vitz, W. Deese, and T.P. Silverstein (2002) Workshop Co-coordinators
for
"Developing Demonstrations for the Chemistry Classroom" 17th Biennial
Conference on Chemical Education, Bellingham, WA, July 2002.
T.P. Silverstein (2000) "Electron Transfer Steps Within Redox Enzymes:
Using
Thermodynamics as a Guide" 219th ACS National Meeting,
SF, CA, Mar. 2000.
D.E. Goodney, C.P. Brink, & T.P. Silverstein (2000) "Spiral/Case
Study Approach to Introductory Chemistry" 219th CS National Meeting,
SF, CA Mar. 2000.
T.P. Silverstein (2000) "Chemical Applications and Analogies:
The Real Reason
Why Oil and Water Don't Mix, and the Big Dog/Puppy Dog'
Analogy for
Resonance" 219th ACS National Meeting, SF, CA, March 2000.
T.P. Silverstein and J.F. Allen (1999) "A Redox-Controlled, pH-Dependent
Thylakoid Protein Kinase: Is Plastoquinol the Activating Ligand?"
American Chemical Society Regional Meeting, Portland, OR; June 1999.
J. Koivisto, K. Olsen, and T.P. Silverstein (1999) "Low pH Does not
Alter the Sodium Permeability of Frog Skin" Proc. OR Acad. Sci. 35,
20.
K. Olsen, and T.P. Silverstein (1999) "The Orange Clock Demonstration:
Is H+ Really the Electron Acceptor at the Cathode?" Proc. OR
Acad. Sci. 35, 23.
T.P. Silverstein and J.F. Allen (1998) "Influence of pH on the Redox
Control of Thylakoid Protein Phosphorylation" EUCHEM Protein Phosphorylation Conference, Stockholm, Sweden; Aug. 1998.
T.P. Silverstein, J.F.Allen (1998) "A Redox-Controlled, pH-Dependent
Thylakoid Protein Kinase: Is Plastoquinol the Activating Ligand?
Bphys.J. 74(2), A79.
T.P. Silverstein (1996) "Explaining Enzyme Kinetics Using the 'Butcher' Analogy" 14th Biennial Conf. on Chem. Educ'n, 4-8 Aug.
Clemson SC.
T.P. Silverstein, C.P. Brink, N.J. Hudak, D.E. Goodney (1996) "A Novel Approach to Introductory Chemistry: The 'Spiral/Case Study'
Approach"
14th Biennial Conference on Chemical Education, 4-8 Aug., Clemson
SC.
C.P. Brink, T.P. Silverstein, D.E. Goodney, N.J. Hudak (1996) "The Spiral Case Study Approach to Intro. Chem." Project Kaleidoscope Workshop: Revitalizing Introductory Chemistry, 15 March 1996, Columbia
Univ., NY.
T.P. Silverstein, L. Cheng, J.F.Allen (1994) "Redox Titration of Chloroplast Thylakoid Protein Phosphorylation: Evidence for a Single
Redox-Controlled Kinase and a Redox-Independent Phosphatase" Biophysical J. 66(2),
A114.
J.R. Rose´ and T.P. Silverstein (1991) "Quinone Redox Potentials:
The Medium is the Message, or, the Variation of E° with Dielectric
Constant." Biophysical Journal 59, 519a.
T.P. Silverstein & L.A. Braby (1990) "Membrane Proteins Sensitize
Sonicated Lipid Membranes to Radiation Damage" Biophysical Journal 57,
270a.
T.P. Silverstein and L.A. Braby (1989) "Large Radiation Doses Leave
Sonicated Lipid Vesicles Intact" Biophysical Journal 55, 115a.
T.P. Silverstein and H. Rottenberg (1987) "Dynamic Protein Aggregates
in the Mitochrondrial Inner Membrane Probed by Time-Resolved Anisotropy
Measurements of Erythrosin-Labeled F1," Biophysical Journal 51, 489a.
T.P. Silverstein and W.L. Hubbell (1985) "Molecular Dynamics at Membrane
Surfaces Probed by Spin Exchange," Biophysical J. 47, 364a.
PUBLICATIONS (OPINION ESSAYS);
T. P. Silverstein (2006) “State Functions vs. State Governments” J. Chem. Educ. 83(6), 847.
T. P. Silverstein (2006) Reply to “Sugar Dehydration without Sulfuric Acid” J. Chem. Educ. 83(5), 701.
T. P. Silverstein (2005) “Chemistry as General Education” J. Chem. Ed. 82, 838.
T.P. Silverstein, D. Goodney, K. Holman, S. Kirk, J. Willemsen, J.C. Williamson (2003) "Model Introductory Chemistry Courses" Chem. & Eng. News 81(7), 6.
T.P. Silverstein (2002) "Climate Change Debate" Chem. & Eng. News 80 (23), 6.
T.P. Silverstein (1999) "New vs. Old Pennies: Chemistry" Science News (March 27, 1999) 155(13), 195.
T.P. Silverstein (1999), book review of Principles of Physical Biochemistry, by van Holde, Johnson, and Ho, Prentice-Hall, 1998; published in J. Chem. Ed.,76(4), 474.
T.P. Silverstein (1998) " U.S. Students Not So Bad" The Scientist 12 (20), 8.
T.P. Silverstein (1998) "Toxics Information" Chem. & Eng. News 76 (10), 2.
T.P. Silverstein (1996) "Teaching Evolution" Science 274 (8 Nov.), 904-5.
T.P. Silverstein (1995) "Asymmetry and Fitness: Statistically Significant?" Science News (April 22, 1995) 147(16), 243.
T.P. Silverstein, C.P. Brink, D.E. Goodney, and N.J. Hudak (1995) "Another Innovative Curriculum" Chemical & Engineering News 73 (33), 2-3.
T.P. Silverstein (1991) "Paper vs. Polystyrene: Environmental Effects" Chemical & Engineering News 69 (17), 2-3.
T.P. Silverstein (1990) "Radiation: Fear or Respect?" Chemical & Engineering News 68 (29), 45.
T.P. Silverstein (1990) "Cyanide in Gold Mining" Oregon Conifer 13 (4), 7.
T.P. Silverstein (1989) "Public Image of the Chemical Industry" Chemical & Engineering News 67 (30), 2-3.
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T.P. Silverstein (2006) “To Fight Terrorism, Fight Injustice” Salem Statesman-Journal, August 1, 2006, p. 6C.
T.P. Silverstein (2005) “Support Education for Children of Illegal Immigrants” Salem Statesman-Journal, June 16, 2005, p. 6C.
T.P. Silverstein (2004) “Professor’s Answer to Student’s Virus Question” Salem Statesman-Journal, Sept. 10, 2004, p. 8C.
T.P. Silverstein (2004) “Keep Medical Waste Out” Salem Statesman-Journal, March 27, 2004, p. 6C.
T.P. Silverstein (2003) “Bush Ignores Contrary Facts” Salem Statesman-Journal, July 15, 2003, p. 7C.
T.P. Silverstein (2003) “Municipal Water Costs” Salem Statesman-Journal, Feb. 11, 2003, p. 4C.
T.P. Silverstein (2002) "Bush’s Forest Plan is Ill-Advised" Salem Statesman-Journal, Aug. 29, 2002, p. 6C.
T.P. Silverstein (1999) "Big Cars and Air Pollution" Salem Statesman-Journal July 13, 1999, p. 5C.
T.P. Silverstein (1998) "Timber Rules Can Save Fish" Salem Statesman-Journal Nov. 27, 1998, p. 11C.
T.P. Silverstein (1995) "North Santiam Copper Mine Could Pollute Our Watershed" Salem Statesman-Journal May 27, 1995, p..
T.P. Silverstein (1994) "Oregon Needs Law for Safe Gold Mining" Salem Statesman-Journal Nov. 7, 1994, p. 11A.
MANUSCRIPTS IN PREPARATION:
T.V. Harris, M. Ericksen and T.P. Silverstein "Mercury(II) Inhibits Chymotrypsin both
Competitively, and also by Causing Aggregation; Aggregation Depends on
Enzyme Histidines, not Cysteines"
S. Walsh, B. Creelan and T.P. Silverstein "Inhibition of Restriction Enzymes by
Mercury(II) Can Occur Independently of Cysteine Binding"
T.P. Silverstein, R. Feinman, and E.J. Fine “Applying the Laws of Thermo-dynamics to Low Carb Diets: Calories are NOT all Created Equal”
T.P. Silverstein and J.F. Allen "The pH-Dependency of Redox-Controlled Thylakoid Protein Phosphorylation: Is Plastoquinone the
Redox Sensor?"
T.P. Silverstein and Katy Olsen "The Redox-Driven Orange Juice Clock: Protons are Not Always the Electron Acceptors"
T.P. Silverstein and Tien Dai "Nicotine From Second Hand Smoke Analyzed in Pet Hair"
T.P. Silverstein "The Critical Nature of Protons in Biochemistry"
J.R. Rose and T.P. Silverstein "Quinone Redox Potentials: The
Medium is the Message, or, the Variation of E° with Dielectric Constant."
T.P. Silverstein “Tyrosine-92 at the Active Site of Alliinase Serves Triple Duty in the Enzyme’s Catalytic Cycle”