Scott C. Meyer

Education

B.S., California Polytechnic State University, San Luis Obispo
Ph.D., University of Arizona

Courses

Chem 115 Introductory Chemistry I
Chem 225 Organic Chemistry I
Chem 228 Organic Chemistry II: Bioorganic Emphasis
Chem 346 Experimental Biochemistry I
Chem 351 Biochemistry

Professional Interests

Dr. Scott Meyer is interested in the development of biosensors for the detection of DNA lesions, especially those caused by chemotherapeutic drugs. Tools for the sequence-specific detection of DNA modification could aid in the treatment of cancer patients and facilitate the development of novel chemotherapies. Dr. Meyer is also interested in the effect of mutations on protein stability in regards to ligand binding, as well as the development of novel ligand-receptor pairs through in vitro selection utilizing phage display.

Personal Interests

Publications

Shomin, C.D.; Meyer, S.C.; Ghosh, I.; "Staurosporine Tethered Peptide Ligands for cAMP-dependent Protein Kinase (PKA): Optimization and Selectivity Profiling" Bioorg. Med. Chem., accepted (2009).
Meyer, S.C.; Ghosh, I.; "Phage Display in Biosensors" Springer: New York, NY, submitted, (2009). (Textbook chapter)
Meyer, S.C.; Shomin, C.D.; Gaj, T.; Ghosh, I.; "Tethering Small Molecules to a Phage Display Library: Discovery of a Selective Bivalent Inhibitor of Protein Kinase A" J. Am. Chem. Soc., 129, 13812-13813 (2007).
Gaj, T.; Meyer, S.C.; Ghosh, I.; "The AviD-tag, a NeutrAvidin/avidin specific peptide affinity tag for the immobilization and purification of recombinant proteins" Protein. Expres. Purif., 56 (1), 54-61 (2007).
Smith, T.J.; Stains, C.I.; Meyer, S.C.; Ghosh, I.; "Inhibition of beta-Amyloid Fibrillization by Directed Evolution of a beta-Sheet Presenting Miniature Protein" J. Am. Chem. Soc., 128 (45), 14456-14457 (2006).
Rajagopal, S.; Meyer, S.C.; Goldman, A.; Zhou, M.; Ghosh, I.; "A Minimalist Approach towards Protein Recognition by Epitope Transfer from Functionally Evolved Beta-Sheet Surfaces" J. Am. Chem. Soc., 128 (44), 14356-14363 (2006).
Meyer, S.C.; Gaj, T.; Ghosh, I.; "Highly Selective Cyclic Peptide Ligands for NeutrAvidin and Avidin Identified by Phage Display" Chem. Biol. Drug Des., 68 (1), 3-10 (2006).
Meyer, S.C.; Huerta, C; Ghosh, I.; Single-Site Mutations in a Hyperthermophilic Variant of the B1 Domain of Protein G Result in Self-Assembled Spherical Oligomers Biochemistry, 44 (7), 2360 -2368 (2005).