Education
- Ph.D., University of California, Berkeley
- B.A., Middlebury College
Courses
- Chem 115 Introductory Chemistry I
- Chem 116 Introductory Chemistry II
- Chem 225 Organic Chemistry I
- Chem 226 Organic Chemistry II
- Chem 430 Advanced Topics in Chemistry
Research Interests
Chemical Synthesis
Chitosan -- a polysaccharide derived from the shells of crustaceans -- provides an ideal biocompatible platform for the development of polymer-based molecular therapeutics. The Duncan Group is pursuing the synthesis of covalent conjugates between hydrophobic small molecule drugs and water-soluble chitosans. We are particularly interested in developing methods for coupling antioxidants to chitosan scaffolds and using the resulting conjugates to prevent oxidative damage to cellular structures.
Personal Interests
Mountaineering, Backpacking, Skiing, Rock Climbing, Food, Wine, Beer
Publications
S.T. Heller, A.P. Duncan, C.L. Moy, S.R. Kirk “The Value of Failure: A Student-Driven Course-Based Research Experience in an Undergraduate Organic Chemistry Lab Inspired by an Unexpected Result” J. Chem. Educ. 2020, 97, 3609.
V.P. Narayanaswamy, A.P. Duncan, S.M. Baker, W.P. Wiesmann, J.J. LiPuma, S.M. Townsend. “In Vitro Activity of a Novel Glycopolymer against Biofilms of Burkholderia cepacia Complex Cystic Fibrosis Clinical Isolates” Antimicrobial Agents and Chemotherapy, 2019, 63, 1.
A.P. Duncan, A.R. ]ohnson. "A 'Classic Papers' Approach to Teaching Undergraduate Organometallic Chemistry" J. Chem. Educ., 2007, 84, 443.
F.E. Michael, A.P. Duncan, Z.K. Sweeney, R.G. Bergman. "Rearrangements and Stereomutations of Metallacycles Derived from Allenes and Imidozirconium Complexes" J. Am. Chem. Soc., 2005, 127, 1752.
A.P. Duncan, J.L. Leighton. "Enantioselective Cu-Catalyzed Conjugate Addition of Diethylzinc to Acyclic Aliphatic Enones" Org. Lett., 2004, 6, 4117.
F.E. Michael, A.P. Duncan, Z.K. Sweeney, R.G. Bergman. "Mechanisms of Allene Stereoinversion by Imidozirconium Complexes" J. Am. Chem. Soc., 2003, 125, 7784.
A.P. Duncan, R.G. Bergman. "Selective Transformations of Organic Molecules by Imidozirconocene Complexes" The Chemical Record, 2002, 2 , 431.
A.P. Duncan, S.M. Mullins, J. Arnold, R.G. Bergman. "Synthesis, Structural Investigation, and Reactivity of Neutral and Cationic Bis(guanidinato)zirconium(IV) Complexes" Organometallics, 2001, 20, 1808.
S.M. Mullins, A.P. Duncan, R.G. Bergman, J. Arnold. "Reactivity of a Titanium Dinitrogen Complex Supported by Guanidinate Ligands: Investigation of Solution Behavior and a Novel Rearrangement of Guanidinate Ligands" Inorg. Chem., 2001, 40, 6952.